The Guiding Principle of Chiral Innovative drugs clearly stipulates that "the direct method for determination of molecular configuration of chiral drugs is single crystal X-ray structure analysis".

Unlike powder XRD, which is widely used in the late stage of drug development and production, single crystal X-ray diffraction technology plays an important role in the early and middle stages of drug development.

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In drug research and development, crystal research runs through all stages from the screening of lead compounds to the final drug marketing.

Micro-xrd can analyze the original state of the sample and carry out phase analysis of various parts of the sample. In this paper, a geological sample lapis Lazuli is taken as an example to further illustrate the effect of micro-diffraction.

Polymers are commonly synthesized as fibers, sheets, and other solid forms. Its properties are greatly affected by its structural parameters such as crystallinity, crystal structure and orientation, and can be studied using XRD

X-ray diffraction is divided into two kinds of single crystal diffraction and powder diffraction, single crystal is mainly used for the determination of molecular weight and crystal structure, powder is mainly used for the identification and purity of crystalline substances.

GIWAXS is a technique to characterize the internal microstructure of thin film samples. The corresponding structure size is between 10nm and 1um, so it is widely used to characterize the crystallization inside solar thin film cells.

HRXRD is a powerful non-destructive testing method, and its research objects are mainly single crystal materials, single crystal epitaxial thin film materials and various low-dimensional semiconductor heterostructures.

The polycrystalline phenomenon of drugs refers to the formation of different crystal states of a compound molecule in the solid state due to the different crystal arrangement and filling methods. ​

In the process of drug development, the properties and structure of drug crystal powders play a crucial role in their efficacy and safety, and the application of X-ray diffraction (XRD) technology provides us with a powerful tool.