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Small Angle X-ray scattering (SAXS) is a technology that collects scattered signals generated by X-rays passing through a sample to study the structural information of a sample in the range of 1~100 nm.
Most drugs exist in the form of crystals, using X-ray diffraction, we can obtain the diffraction information of drug characteristics for each different crystal type.
The Guiding Principle of Chiral Innovative drugs clearly stipulates that "the direct method for determination of molecular configuration of chiral drugs is single crystal X-ray structure analysis".
X-ray diffraction is an important means for people to understand and explore nature, especially in condensed matter physics, life medicine, history and many other fields play an active role.
Unlike powder XRD, which is widely used in the late stage of drug development and production, single crystal X-ray diffraction technology plays an important role in the early and middle stages of drug development.
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With the gradual increase of drug crystal regulation, the quantitative analysis of the effective crystal in drug preparations is a very important link in the quality control process of drug production.
XRD technology is widely used in the fields of crystallography, physics and metallurgy, including qualitative and quantitative, crystal structure, mechanical analysis, etc. This paper mainly lists its application in polymer research.
In drug research and development, crystal research runs through all stages from the screening of lead compounds to the final drug marketing.
Petrological studies often require the identification of mineral compositions in rocks, especially those that are less abundant. Therefore, the qualitative analysis of minerals is the most important application of X-ray diffraction in the study of mineral petrology.
Almost all analytical laboratories supporting the pharmaceutical industry have both thermal analysis instruments and X-ray powder diffractometers. Combining DSC and XRD into one simultaneous measurement, thermal data and diffraction data on the same sample can obtain rich information.
Polymers are commonly synthesized as fibers, sheets, and other solid forms. Its properties are greatly affected by its structural parameters such as crystallinity, crystal structure and orientation, and can be studied using XRD